Journal article
The life history of neochromosomes revealed
AT Papenfuss, DM Thomas
Molecular and Cellular Oncology | TAYLOR & FRANCIS INC | Published : 2015
Abstract
Neochromosomes are a little-studied class of chromosome-scale mutations that drive some cancers. By sequencing isolated neochromosomes from liposarcomas, we recently defined their structure at single-nucleotide resolution and proposed a model for their life history. Here, we summarize that work, highlighting significant aspects and providing historical context and insight into the discovery process.
Grants
Awarded by National Health and Medical Research Council
Funding Acknowledgements
DMT and ATP were supported by a National Health and Medical Research Council (NHMRC) Project Grant (1004022) and the Liddy Shriver Sarcoma Initiative. DMT was supported by an NHMRC Senior Research Fellowship (1003929). ATP was supported by an NHMRC Career Development Fellowship (1003856) and an NHMRC Program Grant (1054618). The work benefitted from support by the Victorian State Government Operational Infrastructure Support and Australian Government NHMRC IRIISS.